Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Jun;73(6):431-6.
doi: 10.1177/014107688007300608.

Neuropharmacological agents modifying endotoxin-induced changes in mice

D J Wright, M P Weller

Neuropharmacological agents modifying endotoxin-induced changes in mice

D J Wright et al. J R Soc Med. 1980 Jun.

Abstract

A variety of neuropharmacological agents were tested to elucidate how chlorpromazine influenced an endotoxin-induced reaction. The results obtained, particularly with beta-adrenergic blocking agents, reserpine and fusaric acid, suggested that the primary locus of chlorpromazine's action was mediated by peripheral beta-adrenergic receptor blockade. Such a locus is compatible with the low doses of propranolol which suppress the reaction, and with successful treatment of shock with dopamine.

PubMed Disclaimer

References

    1. Proc Soc Exp Biol Med. 1971 May;137(1):334-40 - PubMed
    1. Life Sci. 1974 Feb 1;14(3):415-23 - PubMed
    1. Mol Pharmacol. 1976 Mar;12(2):251-62 - PubMed
    1. Nature. 1957 Nov 30;180(4596):1200 - PubMed
    1. Life Sci. 1975 Dec 1;17(11):1715-9 - PubMed

LinkOut - more resources