Somatostatin inhibition of glucagon-stimulated jejunal secretion in the dog

Abstract

The aim of this study was to determine whether somatostatin had any effect on basal jejunal water and electrolyte fluxes, and whether it would inhibit glucagon-stimulated jejunal secretion in the conscious dog. Experiments were performed in 3 dogs with established jejunal fistulas by using the triple-lumen gut perfusion technique. Net water and electrolyte fluxes were measured during intravenous infusions of 150 mM NaCl, glucagon (30 micrograms . kg-1 . h-1), somatostatin (4 micrograms . kg-12 . h-1), and somatostatin plus glucagon. Results showed that glucagon stimulated jejunal water and electrolyte secretion (6 studies). This effect could be completely blocked by somatostatin infused before and with the glucagon (6 studies). In addition, established glucagon-stimulated secretion could be reversed to absorption by addition of somatostatin (6 studies). Somatostatin alone produced no change in net jejunal water and electrolyte fluxes.