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. 1980;28(6):901-6.

The importance of human intestinal diamine oxidase in the oxidation of histamine and/or putrescine

T Biegański, J Kusche, K D Feussner, R Hesterberg, H Richter, W Lorenz
  • PMID: 6114722

The importance of human intestinal diamine oxidase in the oxidation of histamine and/or putrescine

T Biegański et al. Arch Immunol Ther Exp (Warsz). 1980.

Abstract

Histamine, naturally methylated histamine and putrescine are good substrates for human intestinal diamine oxidase, N-Methyl-N-formylhydrazine, the constituent of the mashroom poison-gyromitrin is an inhibitor of human intestinal diamine oxidase. Burimamide inhibits more effectively mammalian intestinal diamine oxidases than pea seedling diamine oxidase, beta-aminopropionitrile is a better inhibitor of pea seedling enzyme than mammalian diamine oxidases. This inhibitory differences might be related to preference in histamine or putrescine oxidizing activity of these enzymes.

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