Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Aug;90(2):300-8.
doi: 10.1083/jcb.90.2.300.

Taxol induces postmitotic myoblasts to assemble interdigitating microtubule-myosin arrays that exclude actin filaments

P B Antin, S Forry-Schaudies, T M Friedman, S J Tapscott, H Holtzer

Taxol induces postmitotic myoblasts to assemble interdigitating microtubule-myosin arrays that exclude actin filaments

P B Antin et al. J Cell Biol. 1981 Aug.

Abstract

Taxol has the following effects on myogenic cultures: (a) it blocks cell replication of presumptive myoblasts and fibroblasts. (b) It induces the aggregation of microtubules into sheets or massive cables in presumptive myoblasts and fibroblasts, but not in postmitotic, mononucleated myoblasts. (c) It induces normally elongated postmitotic myoblasts to form stubby, star-shaped cells. (d) It reversibly blocks the fusion of the star-shaped myoblasts into multinucleated myotubes. (e) It augments the number of microtubules in postmitotic myoblasts, and these are assembled into interdigitating arrays of microtubules and myosin filaments. (f) Actin filaments are largely excluded from these interdigitating microtubule-myosin complexes. (g) The myosin filaments in the interdigitating microtubule-myosin arrays are aligned laterally, forming A-bands approximately 1.5 micrometers long.

PubMed Disclaimer

References

    1. J Cell Biol. 1968 Sep;38(3):538-55 - PubMed
    1. J Cell Biol. 1968 Dec;39(3):544-55 - PubMed
    1. J Cell Biol. 1969 Nov;43(2):312-28 - PubMed
    1. J Cell Biol. 1970 Aug;46(2):199-219 - PubMed
    1. Fed Proc. 1974 Feb;33(2):152-7 - PubMed

Publication types