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. 1981 Jul;78(7):4571-5.
doi: 10.1073/pnas.78.7.4571.

Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi

S G Baum, M Wittner, J P Nadler, S B Horwitz, J E Dennis, P B Schiff, H B Tanowitz

Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi

S G Baum et al. Proc Natl Acad Sci U S A. 1981 Jul.

Abstract

Taxol, an experimental antitumor agent and stabilizer of microtubules, inhibits in vitro replication of the human pathogenic hemoflagellate Trypanosoma cruzi. Micromolar concentrations of the drug prevent the completion of cell division in these organisms but allow the multiplication of cell organelles such as the nucleus, kinetoplast, and flagellum. The result is the formation of motile organisms that have extra organelles but cannot fully replicate. Division proceeds to a relatively fixed locus on the long axis of the organism, suggesting the presence of a specific affected structure or function at this site. It is postulated that taxol produces these effects by stabilizing a portion of the microtubular cytoskeleton of T. cruzi.

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References

    1. J Protozool. 1970 Feb;17(1):39-51 - PubMed
    1. J Am Chem Soc. 1971 May 5;93(9):2325-7 - PubMed
    1. J Protozool. 1974 Feb;21(1):48-52 - PubMed
    1. J Protozool. 1976 Aug;23(3):385-90 - PubMed
    1. Acta Trop. 1978 Sep;35(3):229-37 - PubMed

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