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. 1981 Dec;138(12):1620-1.
doi: 10.1176/ajp.138.12.1620.

Neuroleptic-free intervals in the treatment of schizophrenia

J Pyke, M V Seeman

Neuroleptic-free intervals in the treatment of schizophrenia

J Pyke et al. Am J Psychiatry. 1981 Dec.

Abstract

During a period of 1-2 1/2 years the neuroleptic regimen of 14 schizophrenic outpatients was interrupted every 6 months by drug holidays of 6 weeks' duration. As a result, 10 patients achieved a substantially reduced maintenance dose. The authors were unable to predict for whom the drug holidays would be safe.

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