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. 1981 Nov;78(11):7219-23.
doi: 10.1073/pnas.78.11.7219.

Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide

A Goldstein, W Fischli, L I Lowney, M Hunkapiller, L Hood

Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide

A Goldstein et al. Proc Natl Acad Sci U S A. 1981 Nov.

Abstract

The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary, has been determined. It is (H)Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln(OH). The synthetic peptide with this sequence behaves identically to natural dynorphin in a number of ways, and it has the same potency in the guinea pig ileum myenteric plexus--longitudinal muscle bioassay. The potency is accounted for by the first 13 residues.

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References

    1. Proc Natl Acad Sci U S A. 1979 Dec;76(12):6666-70 - PubMed
    1. Eur J Biochem. 1975 Jun;54(2):577-84 - PubMed
    1. Life Sci. 1975 Jun 15;16(12):1777-82 - PubMed
    1. Hoppe Seylers Z Physiol Chem. 1973 Oct-Nov;354(10-11):1317-26 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Oct;77(10):6207-10 - PubMed

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