Comparative Study
doi: 10.1007/BF01989898.
Physiological mechanism by which acetyl CoA carboxylase is regulated
- PMID: 6119225
- DOI: 10.1007/BF01989898
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Comparative Study
Physiological mechanism by which acetyl CoA carboxylase is regulated
Experientia.
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Abstract
Compared with rats fed a normal diet, the activity of the protein inhibitor of acetyl CoA carboxylase in rat liver doubled after 48 h of fasting. Conversely, acetyl CoA carboxylase activity was diminished by nearly one half. In animals fasted and then subsequently refed a fat free diet, acetyl CoA carboxylase activity was elevated by nearly 9-fold, with a concomitant decrease in the activity of the protein inhibitor by about 9-fold as compared to fasted rats. Hence it appears that the regulatory protein inhibitor for acetyl CoA carboxylase is of physiological significance for fatty acid biosynthesis.
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