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. 1981 Jul 15;198(1):243-6.
doi: 10.1042/bj1980243.

Glutathione utilization by lactating bovine mammary secretory tissue in vitro

C R Baumrucker, P A Pocius, T L Riss

Glutathione utilization by lactating bovine mammary secretory tissue in vitro

C R Baumrucker et al. Biochem J. .

Abstract

gamma-Glutamyltransferase (D-glutamyl transpeptidase, EC 2.3.2.2) activity has been shown to be located predominantly on the extracellular surface of the plasma membrane of lactating bovine mammary cells. Radioactive label from both oxidized ([14C]-gamma-glutamyl) and reduced ([35S]cysteinyl) glutathione was taken up and incorporated into acid-precipitable proteins of mammary tissue. Uptake was shown to involve the transport of free amino acids, and incorporation was shown to involve the action of gamma-=glutamyltransferase. These results indicate that lactating mammary tissue utilizes the constituent amino acids of glutathione for milk-protein synthesis.

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