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. 1981 Sep-Oct;30(5):355-66.

Oxidation of beta-DL-thiaproline, a possible natural substrate of D-aminoacid oxidase

C Foppoli, C Cini, C Blarzino, C de Marco
  • PMID: 6120148

Oxidation of beta-DL-thiaproline, a possible natural substrate of D-aminoacid oxidase

C Foppoli et al. Ital J Biochem. 1981 Sep-Oct.

Abstract

Beta-DL-Thiaproline (thiazolidine 2-carboxylic acid) is a good substrate for hog kidney D-aminoacid oxidase. Unlike other known substrates, beta-thiaproline is better oxidized at neutral than at alkaline pH. At neutral pH beta-thiaproline is a better substrate than D-proline. Beta-DL-thiaproline is fully oxidized to delta 2 thiazoline 2-carboxylic acid, which in acidic medium is hydrolyzed to N-oxalylcysteamine. These results may support the suggestion that beta-thiaproline, arising in vivo from cysteamine and glyoxylate, can be a possible physiological substrate for D-aminoacid oxidase.

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