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. 1982 Jan 30;1(8266):251-3.
doi: 10.1016/s0140-6736(82)90977-1.

Immune response in neonates to hepatitis B vaccine

F Barin, A Goudeau, F Denis, B Yvonnet, J P Chiron, P Coursaget, I D Mar

Immune response in neonates to hepatitis B vaccine

F Barin et al. Lancet. .

Abstract

Three injections of alum hepatitis B vaccine (HB vaccine) were given to 26 Senegalese infants, the first when they were less than 1 month old, and the second and third after 1-month intervals. 94.7% of the neonates whose serum was negative for hepatitis B surface antigen and antibodies against the surface antigen (anti-HBs) showed a specific anti-HBs response. Anti-HBs titres in the neonates were similar to those previously obtained in Senegalese children aged aged 1-24 months. HB vaccine was without sid-effects and was immunogenic in the neonates, irrespective of the hepatitis-B-marker status of the mothers or the children.

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