Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Oct;19(9-10):909-19.
doi: 10.1007/BF00504256.

Genetic and biochemical studies of the highly active esterases A' and B associated with organophosphate resistance in mosquitoes of the Culex pipiens complex

N Pasteur, A Iseki, G P Georghiou

Genetic and biochemical studies of the highly active esterases A' and B associated with organophosphate resistance in mosquitoes of the Culex pipiens complex

N Pasteur et al. Biochem Genet. 1981 Oct.

Abstract

The highly active esterases A' and B that cannot be dissociated from OP resistance in Culex pipiens from France and California are shown to have equivalent Km values (2.1 x 10(-6) M/min/mosquito) but different turnover rates (Vm = 2.13 and 0.57 x 10(-6) M/min/mosquito, respectively) and pH for maximum activity. Both enzymes have broad substrate specificities and at least one, esterase A', can hydrolyze OP insecticides. In addition, esterases A' and B are coded by two closely linked genes, Est-3 and Est-2, respectively (0.67 unit of crossing over), located on the same autosome as pl, a locus attributed to linkage group III. The estimated distance between Est-2 and pl was 9.4 units.

PubMed Disclaimer

References

    1. Can J Genet Cytol. 1974 Dec;16(4):837-50 - PubMed
    1. Jpn J Exp Med. 1969 Feb;39(1):13-6 - PubMed
    1. Biochem Genet. 1976 Jun;14(5-6):481-93 - PubMed
    1. J Econ Entomol. 1978 Apr 17;71(2):201-5 - PubMed
    1. Biochem Genet. 1981 Jun;19(5-6):499-508 - PubMed

Publication types