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Clinical Trial
. 1981 Nov;12(5):721-4.
doi: 10.1111/j.1365-2125.1981.tb01295.x.

Speed of onset of pharmacodynamic activity of propranolol, practolol, oxprenolol and metoprolol after intravenous infection in man

R Lochan, B Silke, S H Taylor
Clinical Trial

Speed of onset of pharmacodynamic activity of propranolol, practolol, oxprenolol and metoprolol after intravenous infection in man

R Lochan et al. Br J Clin Pharmacol. 1981 Nov.

Abstract

1 The speed of onset of the pharmacodynamic activity of intravenous propranolol, practolol, oxprenolol and metoprolol was determined, using attenuation of isoprenaline-induced tachycardia as the end-point, in 16 patients with clinically coronary heart disease. 2 Antagonism was evident within 15 s of injection into the central circulation of all four drugs. The time to maximum attenuation of isoprenaline tachycardia was significantly more rapid with propranolol and oxprenolol than with practolol and metoprolol.

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