doi: 10.1016/s0140-6736(82)92277-2.
Intragastric acidity, bacteria, nitrite, and N-nitroso compounds before, during, and after cimetidine treatment
- PMID: 6122891
- DOI: 10.1016/s0140-6736(82)92277-2
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Intragastric acidity, bacteria, nitrite, and N-nitroso compounds before, during, and after cimetidine treatment
Lancet.
.
Abstract
Eight healthy subjects were studied half-hourly or hourly for 24 h periods before, during, and after cimetidine treatment. No significant differences in intragastric bacterial counts or bacterial species or in intragastric nitrite or N-nitroso-compound concentrations were found as a result of cimetidine treatment. Bacterial counts and nitrite concentrations tended to increase with pH, but N-nitroso-compound concentrations did not. This study provides no evidence that cimetidine treatment may increase the risk of gastric carcinoma by raising N-nitroso-compound concentrations.
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