Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1982 Feb;13(1):10-3.
doi: 10.1055/s-2008-1059589.

Serum concentrations and enzyme induction in epileptic children treated with phenytoin and valproate

F A de Wolff, A C Peters, G M van Kempen
Clinical Trial

Serum concentrations and enzyme induction in epileptic children treated with phenytoin and valproate

F A de Wolff et al. Neuropediatrics. 1982 Feb.

Abstract

In a group of 59 epileptic children treated with phenytoin (PHT) and valproate sodium (VPA), either alone or in combination, the following effects were studied: (1) the reciprocal effect on the serum levels of the two drugs, and (2) the enzyme-inducing effects of both drugs. VPA had no effect on PHT levels, but PHT significantly decreased VPA concentrations. PHT enhanced both gamma-glutamyltranspeptidase activity (gamma-GT) and D-glucaric acid excretion (GLA); these effects were potentiated by VPA. VPA alone did not affect gamma-GT, but significantly enhanced GLA.

PubMed Disclaimer

Publication types