Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Feb 15;202(2):369-71.
doi: 10.1042/bj2020369.

Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice

P M Royce, J Camakaris, J R Mann, D M Danks

Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice

P M Royce et al. Biochem J. .

Abstract

Lysyl oxidase activity in extracts of skin from 1-day-old Mobr/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mobr/Y mice at 7 days of age with a single subcutaneous injection of 50 micrograms of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.

PubMed Disclaimer

References

    1. Biochem J. 1980 Nov 15;192(2):579-86 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Feb;73(2):604-6 - PubMed
    1. Clin Genet. 1977 Feb;11(2):154-61 - PubMed
    1. J Biol Chem. 1977 Feb 10;252(3):939-42 - PubMed
    1. J Nutr. 1978 Apr;108(4):554-60 - PubMed

Publication types