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. 1982 Apr 15;31(8):1629-32.
doi: 10.1016/0006-2952(82)90391-4.

Binding of [3H]ADTN to rat striatal membranes

W W Templeton, G N Woodruff

Binding of [3H]ADTN to rat striatal membranes

W W Templeton et al. Biochem Pharmacol. .

Abstract

The conformationally restricted dopamine analogue ADTN binds in a specific saturable manner to rat striatal membranes. Analysis of the data suggests a single binding site. Binding of [3H]ADTN is displaced by a wide range of dopamine agonists and antagonists (both typical and atypical). The potency of ADTN derivatives to displace [3H]ADTN correlates well with their activity as agonists in other tests both in vivo and in vitro.

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