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Case Reports
. 1982 Aug 1;50(3):560-5.
doi: 10.1002/1097-0142(19820801)50:3<560::aid-cncr2820500329>3.0.co;2-i.

Immunoreactive somatostatin in catecholamine-producing extra-adrenal paraganglioma

H Saito, S Saito, T Sano, N Kagawa, K Hizawa, K Tatara
Case Reports

Immunoreactive somatostatin in catecholamine-producing extra-adrenal paraganglioma

H Saito et al. Cancer. .

Abstract

A patient with catecholamine-producing extra-adrenal paraganglioma was found to have a high concentration of immunoreactive somatostatin (IR-SRIF) in the peripheral blood plasma (47.0 pg/ml, normal; 13.3 +/- 5.3 pg/ml, mean +/- SD). After removal of the tumor, the plasma SRIF level fell within normal range (8.7 pg/ml). In the resected tumor, a considerable amount of IR-SRIF (71.0 ng/g wet weight)( was also detected and SRIF-positive tumor cells were demonstrated by the immunoperoxidase technique. Chromatographic analysis of an extract of the tumor showed the presence of two IR-SRIF components of large molecular size besides a component consistent with authentic tetradecapeptide SRIF (SRIF 14), and one of these had the same molecular size as octacosapeptide SRIF (SRIF 28). This seems to be the first report of a catecholamine-producing extra-adrenal paraganglioma that produces IR-SRIF with molecular heterogeneity.

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