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. 1982;54(1-2):129-34.
doi: 10.1007/BF01249286.

Relatively high levels of dopamine in nucleus accumbens of levodopa treated patients with Parkinson's disease

M Goldstein, A Lieberman, J Pearson

Relatively high levels of dopamine in nucleus accumbens of levodopa treated patients with Parkinson's disease

M Goldstein et al. J Neural Transm. 1982.

Abstract

The dopamine levels were found to be low in the putamen and relatively high in the nucleus accumbens in two Parkinson disease patients treated with levodopa up to the time of their deaths. Tyrosine hydroxylase immunocytochemistry revealed a severe degeneration of the nigro-striatal dopamine neuronal system in both postmortem brains. The relatively high dopamine levels in the nucleus accumbens may be responsible for the occurrence of dyskinesias.

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References

    1. Adv Biochem Psychopharmacol. 1978;19:293-300 - PubMed
    1. Life Sci. 1978 Sep 11;23(10):1049-52 - PubMed
    1. Mol Pharmacol. 1980 Jan;17(1):79-85 - PubMed
    1. Brain Res. 1979 Apr 13;165(2):333-7 - PubMed
    1. Psychopharmacologia. 1975 Dec 31;45(2):151-5 - PubMed

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