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. 1982 Nov 19;85(2):225-7.
doi: 10.1016/0014-2999(82)90471-x.

Divergent effects of cyproheptadine and R 50 656, a 5-HT2 antagonist, on the cardiovascular response to 5-hydroxytryptamine in rats

M K Krstić, Z S Katusić

Divergent effects of cyproheptadine and R 50 656, a 5-HT2 antagonist, on the cardiovascular response to 5-hydroxytryptamine in rats

M K Krstić et al. Eur J Pharmacol. .

Abstract

Cyproheptadine and R 50 656, a novel 5-HT2 antagonist, produced a dose-dependent suppression of the pressor response to 5-hydroxytryptamine (5-HT), but did not affect the depressor response. The pressor effect of 5-HT was significantly more sensitive to R 50 656 than to cyproheptadine. On the contrary, the tachycardic response to 5-HT was antagonized only with cyproheptadine. Accordingly, in rats the 5-HT receptors of cardiac tissue differ in their pharmacological properties from both the excitatory and inhibitory 5-HT receptors of vascular smooth muscle.

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