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. 1983 Feb;18(1):11-4.
doi: 10.1007/BF02774854.

Brain tyrosine hydroxylase activity and calculated amount of brain dopa synthesized in carbon tetrachloride-intoxicated rats

N Takei, A Watanabe, T Sakata, S Hayashi, T Obata, T Shiota, H Nagashima

Brain tyrosine hydroxylase activity and calculated amount of brain dopa synthesized in carbon tetrachloride-intoxicated rats

N Takei et al. Gastroenterol Jpn. 1983 Feb.

Abstract

Tyrosine hydroxylase activity in the corpus striatum was measured in a large dose of carbon tetrachloride (CC14)-intoxicated rats in order to confirm whether brain catecholamine contents decrease in acute hepatic failure or not. Theoretical amounts of dopa synthesized in the brain of the treated animals were calculated according to an equation of enzyme kinetics. Tyrosine hydroxylase activities in CCl4-injured rats were similar to those in control rats, and calculated amounts of brain dopa in liver-injured rats were rather higher as compared to those in untreated animals.

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