Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983;17(3):261-70.
doi: 10.1007/BF00364410.

Genetic basis for Ly-6- defect: complementation between Ly-6- and Thy-1- mutant cell lines

M A Horton, R Hyman

Genetic basis for Ly-6- defect: complementation between Ly-6- and Thy-1- mutant cell lines

M A Horton et al. Immunogenetics. 1983.

Abstract

Selection of antigen loss variants from the BW5147 cell line after chemical mutagenesis, using antibodies to Thy-1.1, Ly-6.2 and H9/25 allospecificities, produced cell lines with a pleiotropic defect in cell surface antigen expression; selection against any antigen led to the loss of all three determinants. The genetic basis for the mutant phenotype has been analyzed by gene complementation by somatic cell hybridization between Ly-6- or H9/25- and Thy-1- mutants, which comprise different Thy-1 gene complementation classes. The Ly-6- and H9/25- mutants can be classified as belonging to either the A or E Thy-1- mutant class.

PubMed Disclaimer

References

    1. J Exp Med. 1972 Mar 1;135(3):443-57 - PubMed
    1. Cell Immunol. 1981 Oct;64(1):187-91 - PubMed
    1. Immunogenetics. 1980;11(3):275-91 - PubMed
    1. J Immunol. 1982 Jan;128(1):201-5 - PubMed
    1. Cell. 1979 Jul;17(3):503-8 - PubMed

Publication types

LinkOut - more resources