doi: 10.1111/j.1399-3011.1983.tb03087.x.
Biological activity of synthetic analogs of serum thymic factor
- PMID: 6131874
- DOI: 10.1111/j.1399-3011.1983.tb03087.x
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Biological activity of synthetic analogs of serum thymic factor
Int J Pept Protein Res.
1983 Feb.
Abstract
A series of analogs of serum thymic factor (Facteur Thymique Sérique; FTS) devoid of C- and N-terminal few residues were synthesized and their ability to induce Thy-l (theta) antigen in vitro on mouse T lymphocyte precursors was examined. The pentapeptide moiety (Lys-Ser-Gln-Gly-Gly) seems to be important for the expression of agonistic activity. Some of the short chain peptides showed antagonistic properties. Synergistic activation by two inactive analogs was observed.
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