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. 1983 Apr 30;1(8331):952-3.
doi: 10.1016/s0140-6736(83)92080-9.

Immunoglobulin allotype markers in gluten-sensitive enteropathy

M F Kagnoff, J B Weiss, R J Brown, T Lee, M S Schanfield

Immunoglobulin allotype markers in gluten-sensitive enteropathy

M F Kagnoff et al. Lancet. .

Abstract

Immunoglobulin allotype markers and HLA-A, HLA-B, and HLA-DR locus antigens were determined in 30 White patients with gluten-sensitive enteropathy and 30 controls matched for age, ethnic background, and geographic origin. All patients lacking HLA-B8 and HLA-DR3 had the IgG (Gm) immunoglobulin heavy-chain phenotype Gm (f;n;b). Thus, in addition to major histocompatibility locus genes, it appears that genes linked to the immunoglobulin heavy-chain allotype locus on chromosome 14 may influence susceptibility in gluten-sensitive enteropathy.

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