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. 1983 Apr 18;32(16):1873-8.
doi: 10.1016/0024-3205(83)90066-8.

In vitro paracrine regulation of islet B-cell function by A and D cells

W Y Fujimoto, S Kawazu, M Ikeuchi, Y Kanazawa

In vitro paracrine regulation of islet B-cell function by A and D cells

W Y Fujimoto et al. Life Sci. .

Abstract

In monolayer cultures of islet cells from neonatal rats, incubation of cells for 1 hour with either anti-somatostatin serum or anti-glucagon serum enhanced insulin release. The former appears to be due to neutralization of endogenously secreted somatostatin. The latter may be due to removal of a stimulatory effect of endogenously released glucagon upon somatostatin secretion. Thus, although exogenously added glucagon stimulates insulin secretion, the effect of endogenously released glucagon upon islet B cells is a restraining one which may be mediated through an effect upon D cells and their release of endogenous somatostatin.

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