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Clinical Trial
. 1983 May 7;1(8332):1003-5.
doi: 10.1016/s0140-6736(83)92640-5.

In-vivo and in-vitro assessment of chloroquine-resistant Plasmodium falciparum malaria in Zanzibar

I K Schwartz, D Payne, C C Campbell, O J Khatib
Clinical Trial

In-vivo and in-vitro assessment of chloroquine-resistant Plasmodium falciparum malaria in Zanzibar

I K Schwartz et al. Lancet. .

Abstract

A population-based field study was conducted in Zanzibar Town, Zanzibar, Tanzania, to assess the in-vivo and in-vitro susceptibility to chloroquine of Plasmodium falciparum. Single-dose therapy with chloroquine (10 mg base/kg) failed to clear parasitaemia in 11 of 22 (50%) treated subjects, and a standard therapeutic regimen of chloroquine (25 mg base/kg) failed to clear parasitaemia in 11 of 32 (34%) treated subjects. Concurrent in-vitro testing by the Rieckmann micromethod showed that 8 of 12 (66%) isolates were chloroquine-resistant.

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