doi: 10.1016/0165-4608(83)90009-2.
Linkage and chromosome study of multiple endocrine neoplasia IIa
- PMID: 6134579
- DOI: 10.1016/0165-4608(83)90009-2
Item in Clipboard
Linkage and chromosome study of multiple endocrine neoplasia IIa
Cancer Genet Cytogenet.
1983 Jul.
Abstract
A linkage and chromosome investigation of a large family with multiple endocrine neoplasia (MEN) IIa (medullary thyroid carcinoma, pheochromocytoma, and occasionally hyperparathyroidism) was undertaken. No significantly positive lodscores were obtained between MEN IIa and 25 different genetic markers. Conventional metaphase chromosome analysis showed normal karyotypes and no heterochromatin markers linked to the MEN IIa locus were found. High-resolution chromosome analysis in five MEN IIa carriers revealed no deletion within band 20p12.2. The present investigation could thus neither demonstrate linkage of the MEN IIa locus to genetic or chromosome markers nor identify chromosome abnormalities in MEN IIa carriers.
Similar articles
-
Early diagnosis of multiple endocrine neoplasia type IIa.Klin Wochenschr. 1989 Sep 15;67(18):951-6. doi: 10.1007/BF01721424. Klin Wochenschr. 1989. PMID: 2571743
-
Linkage analysis of multiple endocrine neoplasia type 2A (MEN-2A) and three DNA markers on chromosome 20: evidence against synteny.Cancer Genet Cytogenet. 1987 Aug;27(2):327-34. doi: 10.1016/0165-4608(87)90015-x. Cancer Genet Cytogenet. 1987. PMID: 2885081
-
Ring chromosome in a patient with MEN IIA S.Cancer Genet Cytogenet. 1989 Jan;37(1):23-7. doi: 10.1016/0165-4608(89)90070-8. Cancer Genet Cytogenet. 1989. PMID: 2563670
-
Multiple endocrine neoplasia (MEN)--an overview and case report--patient with sporadic bilateral pheochromocytoma, hyperparathyroidism and marfanoid habitus.Anticancer Res. 2000 Nov-Dec;20(6C):4877-87. Anticancer Res. 2000. PMID: 11205236 Review.
-
[The genetics of medullary cancer of the thyroid].Ann Endocrinol (Paris). 1988;49(1):4-9. Ann Endocrinol (Paris). 1988. PMID: 2900621 Review. French.
Cited by
-
Linkage analysis of a DNA marker localized to 20p12 and multiple endocrine neoplasia type 2A.Am J Hum Genet. 1985 Sep;37(5):890-7. Am J Hum Genet. 1985. PMID: 2864854 Free PMC article.
-
Cytogenetic studies of individuals from four kindreds with multiple endocrine neoplasia type II syndrome.Cancer Genet Cytogenet. 1987 Oct;28(2):253-60. doi: 10.1016/0165-4608(87)90211-1. Cancer Genet Cytogenet. 1987. PMID: 2887277 Free PMC article.
-
Chromosome 20 deletion in human multiple endocrine neoplasia types 2A and 2B: a double-blind study.Proc Natl Acad Sci U S A. 1984 Apr;81(8):2525-8. doi: 10.1073/pnas.81.8.2525. Proc Natl Acad Sci U S A. 1984. PMID: 6585814 Free PMC article.
-
High resolution chromosome and DNA analysis in multiple endocrine neoplasia type II syndrome.Cancer Genet Cytogenet. 1987 Jan;24(1):129-35. doi: 10.1016/0165-4608(87)90089-6. Cancer Genet Cytogenet. 1987. PMID: 2878715 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
