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. 1983 Sep 10;2(8350):599-602.
doi: 10.1016/s0140-6736(83)90682-7.

Experimental transmission of macaque AIDS by means of inoculation of macaque lymphoma tissue

N L Letvin, W R Aldrich, N W King, B J Blake, M D Daniel, R D Hunt

Experimental transmission of macaque AIDS by means of inoculation of macaque lymphoma tissue

N L Letvin et al. Lancet. .

Abstract

Acquired immuno-deficiency syndrome (AIDS) of macaques, an animal model for human AIDS, was transmitted to previously healthy macaque monkeys by means of inoculation of either tissue or a cell-free filtrate of a macaque lymphoma. The recipients showed evidence of profound lymphocyte dysfunction or died with infections from such opportunistic agents as Candida albicans, Cryptosporidium, and cytomegalovirus.

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