doi: 10.1007/BF00634261.
Effects of DPI (2-(3,4-dihydroxyphenylimino)-imidazolidine) on prejunctional alpha-adrenoceptors and prejunctional dopamine receptors in the rabbit ear artery
- PMID: 6136918
- DOI: 10.1007/BF00634261
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Effects of DPI (2-(3,4-dihydroxyphenylimino)-imidazolidine) on prejunctional alpha-adrenoceptors and prejunctional dopamine receptors in the rabbit ear artery
Naunyn Schmiedebergs Arch Pharmacol.
1983 Jun.
Abstract
The effects of DPI on transmitter noradrenaline release were examined in rabbit isolated ear arteries previously incubated in [ 3H ]noradrenaline. DPI (0.1 mumol/l) reduced transmitter release with periarterial electrical stimulation at 1 Hz (1 ms pulses, supramaximal voltage for 30 s), which is consistent with an agonistic effect of DPI on prejunctional alpha-adrenoceptors. At stimulation frequencies of 2 or 5 Hz DPI alone did not affect release, however in the presence of phentolamine (3 mumol/l, which increased release per se) DPI again significantly reduced release; this effect was blocked by metoclopramide (1 mumol/l) indicating an agonistic effect of DPI on prejunctional dopamine receptors.
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