Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Jun;323(2):141-4.
doi: 10.1007/BF00634261.

Effects of DPI (2-(3,4-dihydroxyphenylimino)-imidazolidine) on prejunctional alpha-adrenoceptors and prejunctional dopamine receptors in the rabbit ear artery

I C Medgett

Effects of DPI (2-(3,4-dihydroxyphenylimino)-imidazolidine) on prejunctional alpha-adrenoceptors and prejunctional dopamine receptors in the rabbit ear artery

I C Medgett. Naunyn Schmiedebergs Arch Pharmacol. 1983 Jun.

Abstract

The effects of DPI on transmitter noradrenaline release were examined in rabbit isolated ear arteries previously incubated in [ 3H ]noradrenaline. DPI (0.1 mumol/l) reduced transmitter release with periarterial electrical stimulation at 1 Hz (1 ms pulses, supramaximal voltage for 30 s), which is consistent with an agonistic effect of DPI on prejunctional alpha-adrenoceptors. At stimulation frequencies of 2 or 5 Hz DPI alone did not affect release, however in the presence of phentolamine (3 mumol/l, which increased release per se) DPI again significantly reduced release; this effect was blocked by metoclopramide (1 mumol/l) indicating an agonistic effect of DPI on prejunctional dopamine receptors.

PubMed Disclaimer

References

    1. Br J Pharmacol. 1978 Dec;64(4):527-37 - PubMed
    1. J Pharm Pharmacol. 1975 Nov;27(11):882-3 - PubMed
    1. Eur J Pharmacol. 1981 Oct 15;75(1):11-9 - PubMed
    1. J Pharmacol Exp Ther. 1979 Jun;209(3):429-36 - PubMed
    1. Br J Pharmacol. 1979 Nov;67(3):420P-421P - PubMed

Publication types