doi: 10.1016/s0031-6989(83)80068-x.
Cholinergic effects of cimetidine and ranitidine
- PMID: 6136992
- DOI: 10.1016/s0031-6989(83)80068-x
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Cholinergic effects of cimetidine and ranitidine
Pharmacol Res Commun.
1983 May.
Abstract
Cimetidine and ranitidine were submitted to eight in vitro assays: their intrinsic activity was evaluated on guinea-pig auricles and ileum, acetylcholine synergism on guinea-pig tracheal muscle, frog rectus abdominis, guinea-pig vas and rat phrenic nerve diaphragm, and antagonism on guinea-pig auricles and rat jejunum estimated at a range of concentrations. Ranitidine alone opposed 1-hyoscyamine antagonism in guinea-pig ileum when acetylcholine was the agonist, but not when the agonist was bethanechol.
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