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. 1983 May;15(5):485-517.
doi: 10.1016/s0031-6989(83)80068-x.

Cholinergic effects of cimetidine and ranitidine

L Re, M L Cingolani, C Concettoni, L Rossini

Cholinergic effects of cimetidine and ranitidine

L Re et al. Pharmacol Res Commun. 1983 May.

Abstract

Cimetidine and ranitidine were submitted to eight in vitro assays: their intrinsic activity was evaluated on guinea-pig auricles and ileum, acetylcholine synergism on guinea-pig tracheal muscle, frog rectus abdominis, guinea-pig vas and rat phrenic nerve diaphragm, and antagonism on guinea-pig auricles and rat jejunum estimated at a range of concentrations. Ranitidine alone opposed 1-hyoscyamine antagonism in guinea-pig ileum when acetylcholine was the agonist, but not when the agonist was bethanechol.

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