Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1983;53-54(1-2):197-220.
doi: 10.1007/BF00225254.

Modulation of poly(A)(+)mRNA-metabolizing and transporting systems under special consideration of microtubule protein and actin

W E Müller, A Bernd, H C Schröder
Review

Modulation of poly(A)(+)mRNA-metabolizing and transporting systems under special consideration of microtubule protein and actin

W E Müller et al. Mol Cell Biochem. 1983.

Abstract

At present, three enzymes are known which participate in regulation of polyadenylation and polydeadenylation of eukaryotic mRNA: poly(A) polymerase, endoribonuclease IV and 2',3'-exoribonuclease. Moreover, poly(A)-associated proteins as well as the cytoskeletal proteins actin and tubulin have been found to be involved in poly(A) metabolism of mRNA; their modulation effects on poly(A) metabolizing enzyme systems will be described in greater detail. Nucleo-cytoplasmic transport of poly(A)-containing mRNA is thought to be mediated by nuclear-envelope nucleoside triphosphatase. The stimulation of this enzyme by the poly(A) segment of mRNA and its modulation by microtubule protein are discussed in the second part of this review.

PubMed Disclaimer

References

    1. J Cell Biol. 1978 Mar;76(3):675-91 - PubMed
    1. Exp Cell Res. 1981 Sep;135(1):79-91 - PubMed
    1. Biochim Biophys Acta. 1980 Jul 29;608(2):324-31 - PubMed
    1. J Mol Biol. 1976 Nov;108(1):139-50 - PubMed
    1. J Biol Chem. 1979 Nov 25;254(22):11228-33 - PubMed

Publication types

MeSH terms