Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Nov;97(5 Pt 1):1538-43.
doi: 10.1083/jcb.97.5.1538.

Reappearance of beta-adrenergic receptors after isoproterenol treatment in intact C6-cells

C Hertel, M Staehelin

Reappearance of beta-adrenergic receptors after isoproterenol treatment in intact C6-cells

C Hertel et al. J Cell Biol. 1983 Nov.

Abstract

The reappearance of beta-adrenergic receptors in C6-glioma cells after desensitization with isoproterenol was studied using the antagonist [3H]CGP-12177. Reappearance had the following properties: (a) it occurred in intact cells only, (b) it was temperature dependent, (c) it required an Na+/H+ gradient, low intracellular Ca2+ activity, and (d) it required ATP, and (e) intact lysosomes. The results suggest endocytosis and recycling of the beta-adrenergic receptor after agonist treatment.

PubMed Disclaimer

References

    1. Science. 1968 Jul 26;161(3839):370-1 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1159-63 - PubMed
    1. Biochem Pharmacol. 1974 Sep 15;23(18):2495-531 - PubMed
    1. J Exp Med. 1977 Nov 1;146(5):1332-45 - PubMed
    1. Anal Biochem. 1978 May;86(1):142-6 - PubMed