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. 1983 Oct 25;11(20):7181-90.
doi: 10.1093/nar/11.20.7181.

Molecular cloning and nucleotide sequence of a human renin cDNA fragment

F Soubrier, J J Panthier, P Corvol, F Rougeon
Free PMC article

Molecular cloning and nucleotide sequence of a human renin cDNA fragment

F Soubrier et al. Nucleic Acids Res. .
Free PMC article

Abstract

We have studied human renin messenger RNA by hybridization with the mouse submaxillary gland (SMG) renin cDNA probe. The human kidney messenger RNA is about 1.6 kilobase (kb) long, similarly to the mouse SMG renin mRNA. A kidney renin cDNA clone of 1.1 kb length was obtained. A comparison of nucleotide sequences of mouse and human cDNA clones reveals conservation of residues involved in catalytic mechanisms and a potential glycosylation site. The human renin molecular probe allowed us to study renin expression in human chorionic tissue. The chorionic and kidney renin messenger RNAs are similar in length. The Southern blot analysis reveals the presence of a single renin gene in human DNA.

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References

    1. Am J Obstet Gynecol. 1968 Jun 15;101(4):529-33 - PubMed
    1. Neuropharmacology. 1975 Jan;14(1):75-80 - PubMed
    1. Nucleic Acids Res. 1976 Sep;3(9):2303-8 - PubMed
    1. J Mol Biol. 1977 Jun 15;113(1):237-51 - PubMed
    1. J Biol Chem. 1979 Jun 10;254(11):4848-55 - PubMed

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