[Comparative study of the action of a series of new beta-adrenergic receptor blockaders in patients with effort angina]

Abstract

In 32 patients with angina of effort, the antianginal effects and action duration of propranolol, atenolol, labetalol and nadolol were compared during the exercise test after a single dose of the drug. Atenolol and nadolol have been ascertained to be effective long acting antianginal drugs. Except the antianginal effect duration, the above mentioned beta-blockers have not been found to be superior to propranolol, including to atenolol, to its effect on the total peripheral vascular resistance. Labetalol provided a sufficient antianginal effect in a number of patients, including those in whom propranolol was not effective enough. It have been found that high incidence of side effects makes it inexpedient to use high doses of labetalol (more than 200 mg) in patients with angina pectoris who have normal blood pressure.