Hypophosphataemia: A complication of "innocuous dextrose-saline"

Abstract

Plasma and urinary phosphate levels were studied before and after operation in 13 patients undergoing uncomplicated major surgery. The maintenance intravenous fluid in six patients was 0.9% saline and in the other seven patients it was 4% dextrose with 0.18% saline. Although the plasma-phosphate fell in both groups, reaching minimum on the second postoperative day and then returning towards normal, it was significantly lower in the group receiving dextrose on the second, third, and fourth postoperative days when the levels were below the normal range. It is suggested that when dextrose-saline solutions are indicated in postoperative patients the addition of phosphate to the solution should be considered.