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. 1984 Jan 7;1(8367):14-6.
doi: 10.1016/s0140-6736(84)90182-x.

A rapid screening test for antenatal sex determination

Y F Lau, J C Huang, A M Dozy, Y W Kan

A rapid screening test for antenatal sex determination

Y F Lau et al. Lancet. .

Abstract

A recombinant DNA probe was used for antenatal sex determination. The probe was isolated from the 3.4 kilobase human repeat sequence derived from heterochromatin of the Y chromosome and had 1000 times more affinity for male DNA than for female DNA. A dot blot hybridisation method with 200 microliter of amniotic fluid yielded accurate results in 2 to 3 days. This test should facilitate antenatal diagnosis of sex-linked genetic disorders.

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