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. 1983 Nov 15;216(2):523-5.
doi: 10.1042/bj2160523.

Glutamine synthetase activity of muscle in acidosis

P A King, L Goldstein, E A Newsholme

Glutamine synthetase activity of muscle in acidosis

P A King et al. Biochem J. .

Abstract

Metabolic acidosis stimulates the rate of glutamine release from muscle, and this in turn is used by the kidney in acid-base balance. NH4Cl, HCl or diabetic ketoacidosis increases the maximum activity of glutamine synthetase in skeletal muscle. Starvation and administration of adrenal steroids also increase the activity of the enzyme in muscle.

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