Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Jan;36(1):11-5.
doi: 10.1111/j.2042-7158.1984.tb02978.x.

The ionization of beta-adrenoceptor agonists: a method for unravelling ionization schemes

A P Ijzerman, T Bultsma, H Timmerman, J Zaagsma

The ionization of beta-adrenoceptor agonists: a method for unravelling ionization schemes

A P Ijzerman et al. J Pharm Pharmacol. 1984 Jan.

Abstract

To investigate the ionization schemes of beta-adrenoceptor agonists, a combined electrochemical/uv-spectrophotometric method with computer-assisted data-analysis was developed, yielding the macroscopic and microscopic ionization constants. From the four species possible, cations and zwitterions were found the main species present at physiological pH, the formation of uncharged molecules and anions being less favourable or apparently negligible.

PubMed Disclaimer

LinkOut - more resources