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. 1984 Jan 23;291(2):373-7.
doi: 10.1016/0006-8993(84)91272-1.

Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat

F F Johansen, M B Jørgensen, D K Ekström von Lubitz, N H Diemer

Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat

F F Johansen et al. Brain Res. .

Abstract

In this study of the rat hippocampal CA1 stratum radiatum 4 days after 20 min transient cerebral ischaemia, we demonstrated ultrastructural dendritic degeneration and loss, whereas most axons appeared undamaged. Autoradiographs 4 days after ischaemia showed unchanged Na+-dependent glutamate high affinity uptake. The role of glutamate and Ca2+ for this selective postsynaptic vulnerability is discussed.

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