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. 1984;15(1):51-4.
doi: 10.1016/0306-3623(84)90080-6.

The mechanism of the histamine-induced desensitization of guinea-pig ileum

B Bielkiewicz, D A Cook

The mechanism of the histamine-induced desensitization of guinea-pig ileum

B Bielkiewicz et al. Gen Pharmacol. 1984.

Abstract

Histamine and the selective H1 receptor agonist 2-pyridylethylamine show cross-desensitization when tested in guinea-pig ileum. The H1 receptor blocking agent produces a smaller parallel shift in desensitized tissues when compared with non-desensitized controls. We conclude that desensitization in this system occurs at the receptor level and is reflected by a decreased sensitivity to both agonists and antagonists.

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