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. 1984 Mar 17;1(8377):583-7.
doi: 10.1016/s0140-6736(84)90994-2.

Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy

T E Starzl, M A Nalesnik, K A Porter, M Ho, S Iwatsuki, B P Griffith, J T Rosenthal, T R Hakala, B W Shaw Jr, R L Hardesty, et al.

Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy

T E Starzl et al. Lancet. .

Abstract

Post-transplant lymphomas or other lymphoproliferative lesions, which were usually associated with Epstein-Barr virus infections, developed in 8, 4, 3, and 2 recipients, respectively, of cadaveric kidney, liver, heart, and heart-lung homografts. Reduction or discontinuance of immunosuppression caused regression of the lesions, often without subsequent rejection of the grafts. Chemotherapy and irradiation were not valuable. The findings may influence policies about treating other kinds of post-transplantation neoplasms.

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