[Mathematical aspects of clinico-pharmacokinetic prediction of the effectiveness of treatment]

Abstract

The use of a discriminant analysis for the statistical processing of the findings provided by a study on the prediction of the efficacy of the course therapy was substantiated. The authors described the computer programmes used for pharmacokinetic analysis and analyzed their average statistical resistance to the erroneous measurement of the drug concentration in biomaterial. The techniques of the quantitative evaluation of the real efficacy of the course therapy based on the data on the time-course of the patient's status according to the scale proposed by the All-Union Research Center on Mental Health and the BPRS are outlined.