Muscarinic receptors and [3H]inositol incorporation in a rat sympathetic ganglion

Abstract

[3H]Inositol incorporation into phosphatidylinositol was accelerated in rat superior cervical ganglia treated with 4-aminopyridine or Bethanechol. The inositol response to these drugs occurred in intact and denervated ganglia and was prevented by atropine. The possibility that muscarinic receptor subtypes are present in the ganglia is considered because bethanechol, but not 4-aminopyridine, is known to increase cGMP in rat superior cervical ganglia by an atropine-sensitive process.