Phenotypic heterogeneity of antisyngeneic tumor killer cells (ASTK) generated in allogeneic mixed lymphocyte reactions
- PMID: 6144708
Item in Clipboard
Phenotypic heterogeneity of antisyngeneic tumor killer cells (ASTK) generated in allogeneic mixed lymphocyte reactions
J Immunol.
1984 Jun.
Abstract
By using monoclonal antibodies to Thy-1, Lyt-2, and Qa-5 differentiation antigens, we demonstrated a heterogeneity of cytotoxic cells developed in allogeneic mixed lymphocyte responses that lyse tumor cells syngeneic with the responder cells. There are minimally two Thy-1+ populations, one of which is Lyt-2+ and the other Lyt-2-. There is probably also a Thy-1- population. Most of the Lyt-2- tumor killer cells are Qa-5+, and most of the Lyt-2+ tumor killer cells are Qa-5-.
Similar articles
-
Lack of specificity for viral and H-2 antigens by anomalous T killer cells generated in murine leukocyte cultures.J Immunol. 1982 Aug;129(2):722-9. J Immunol. 1982. PMID: 6177779
-
Cellular requirements for the generation of primary cell-mediated lympholysis responses to Qa-1 antigens.J Immunol. 1985 Apr;134(4):2198-204. J Immunol. 1985. PMID: 3156180
-
Mouse alloantibodies capable of blocking cytotoxic T cell function. V. The majority of I region-specific CTL are Lyt-2+ but are relatively resistant to anti-Lyt-2 blocking.J Immunol. 1984 Feb;132(2):578-83. J Immunol. 1984. PMID: 6197465
-
Effects of anti-Lyt antibodies on T-cell functions.Immunol Rev. 1982;68:43-66. doi: 10.1111/j.1600-065x.1982.tb01059.x. Immunol Rev. 1982. PMID: 6217147 Review. No abstract available.
-
Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes (CTL): possible implications for the affinity of CTL antigen receptors.Immunol Rev. 1982;68:89-115. doi: 10.1111/j.1600-065x.1982.tb01061.x. Immunol Rev. 1982. PMID: 6184308 Review. No abstract available.
Cited by
-
Allostimulation of patients' lymphocytes generates both T and NK-like cells cytotoxic for autologous melanoma.Br J Cancer. 1985 Jul;52(1):73-80. doi: 10.1038/bjc.1985.151. Br J Cancer. 1985. PMID: 3160380 Free PMC article.
-
Pronounced antitumor effect of LAK-like cells induced in the peritoneal cavity of mice after intraperitoneal injection of OK-432, a killed streptococcal preparation.Cancer Immunol Immunother. 1986;22(3):161-8. doi: 10.1007/BF00200027. Cancer Immunol Immunother. 1986. PMID: 2425968 Free PMC article.
-
Adoptive immunotherapy of a BALB/c lymphoma by syngeneic anti-DBA/2 immune lymphoid cells: characterization of the effector population and evidence for the role of the host's non-T cells.Cancer Immunol Immunother. 1985;20(3):198-204. doi: 10.1007/BF00205576. Cancer Immunol Immunother. 1985. PMID: 3851699 Free PMC article.
-
Natural cytotoxic (NC) activity: a multi-lineage system regulated by IL-2.Immunol Res. 1986;5(1):5-15. doi: 10.1007/BF02917189. Immunol Res. 1986. PMID: 3489796 No abstract available.
-
Anti-L3T4 antibody inhibits the lysis of H-2 class II antigen-negative target cells by L3T4+ cytotoxic T lymphocytes.Proc Natl Acad Sci U S A. 1988 Jul;85(14):5205-9. doi: 10.1073/pnas.85.14.5205. Proc Natl Acad Sci U S A. 1988. PMID: 2839834 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
etc
LinkOut - more resources
Miscellaneous