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. 1984 Oct;43(4):1132-5.
doi: 10.1111/j.1471-4159.1984.tb12853.x.

Opiates stimulate low Km GTPase in brain

P H Franklin, W Hoss

Opiates stimulate low Km GTPase in brain

P H Franklin et al. J Neurochem. 1984 Oct.

Abstract

Low Km GTP hydrolysis in rat brain is stimulated in a concentration-dependent manner by the opiate alkaloid etorphine, and by the opioid peptide D-Ala2-leucine-enkephalinamide. The opiate antagonist naloxone inhibits the maximal D-Ala2-leucine-enkephalinamide stimulation of the GTPase, also with concentration dependency. The magnitude of maximally stimulated, opioid-sensitive, GTP hydrolysis is differentially distributed across brain regions. Opioid-stimulated GTPase may represent one means of identifying a specific type of opioid receptor.

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