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. 1984 Sep 17;123(2):648-55.
doi: 10.1016/0006-291x(84)90278-x.

Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide

B D Nelkin, K I Rosenfeld, A de Bustros, S S Leong, B A Roos, S B Baylin

Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide

B D Nelkin et al. Biochem Biophys Res Commun. .

Abstract

Messenger RNAs for calcitonin (CT) and calcitonin gene related peptide (CGRP) have been detected in a human medullary thyroid carcinoma cell line. DNA sequences of their cloned cDNAs, and genomic restriction mapping, indicate that both mRNAs probably originate from a single gene; the separate mRNAs are derived by alternative processing. The calcitonin gene is expressed in 10 of 10 examined culture lines of human lung cancer; most of these lines express a higher ratio of CGRP to CT specific mRNA than does the medullary thyroid carcinoma cell line.

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