[Neuropharmacologic analysis of the dopamin-, cholin- and GABA-ergic systems of the brain in the organization of reflexes to time]

Abstract

Neurochemical mechanisms and structural-functional relations of conditioned reflex to time, temporal prognosing, and trace processes were studied in freely behaving intact cats and cats with lesions of the frontal cortex and the head of the caudate nucleus. It has been found that reactions to time are controlled mainly by cholinergic brain structures, temporal prognosing is controlled by dopaminergic mediation, and the trace phenomena--by GABA-ergic system. The data obtained and the methods applied may be used in analysis of some psychopathological symptoms such as desorientation in time, confabulatory confusion, mnestic disorders.