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. 1984 Nov 19;322(1):124-6.
doi: 10.1016/0006-8993(84)91189-2.

The cortico-nigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the rat

J Kornhuber, J S Kim, M E Kornhuber, H H Kornhuber

The cortico-nigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the rat

J Kornhuber et al. Brain Res. .

Abstract

Unilateral ablation of the frontal cortex results in a significant reduction (19.5%) of glutamic acid in the ipsilateral compared with the contralateral substantia nigra. The GABA level in the substantia nigra and both the glutamate and GABA levels in the hippocampus remain unchanged. The results suggest that glutamate is a transmitter in the cortico-nigral fibre tract.

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